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What treatments are proven to work for COVID-19?

A vaccine probably won't be available to everyone before December 2021 (if at all) but here are some potential treatments for COVID-19.

Julian Talbot

Resources and information about coronavirus

If you share this link and 2 others share it and so on, we use the power of exponential math in our favor. Which seems appropriate given the virus is using that same exponential math against us.

Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19

An anti-malarial drug President Trump has aggressively promoted to treat covid-19 had no benefit and was linked to higher rates of death for Veterans Affairs patients hospitalized with the novel coronavirus, according to a study, raising further questions about the safety and efficacy of a treatment that has seen widespread use in the pandemic. The study by VA and academic researchers analyzed outcomes of 368 male patients nationwide, with 97 receiving hydroxychloroquine, 113 receiving hydroxychloroquine in combination with the antibiotic azithromycin, and 158 not receiving any hydroxychloroquine. Rates of death in the groups treated with the drugs were worse than those who did not receive the drugs, the study found. Rates of patients on ventilators were roughly equal, with no benefit demonstrated by the drugs.

Anti-malarial drug Trump touted is linked to higher rates of death in VA coronavirus patients, study says

Hydroxychloroquine, the anti-malarial drug Trump has touted as a game-changer in treating covid-19, had no benefit and was linked to higher rates of death for Veterans Affairs patients, according to a study. The study by VA and academic researchers analyzed outcomes of 368 male patients nationwide, with 97 receiving hydroxychloroquine, 113 receiving hydroxychloroquine in combination with the antibiotic azithromycin, and 158 not receiving any hydroxychloroquine. Rates of death in the groups treated with the drugs were worse than those who did not receive the drugs, the study found. Rates of patients on ventilators were roughly equal, with no benefit demonstrated by the drugs." The study was published on the site medrxiv.org, which is a clearinghouse for academic studies on the coronavirus that have not yet been peer-reviewed or published in academic journals so it remains to be peer-reviewed but seems credible. https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v2

Chorloquine Can Kill With Just Two Gram Dose

- China recommended chloroquine for coronavirus a month back - Within days, it cautioned against severe side effects - As little as 1 g may be fatal in children. Toxic symptoms can occur within minutes. The best analysis based on multiple forms of administration in different animal models and in human trials is that chloroquine and hydroxychloroquine are equipotent and that chloroquine is approximately twice as toxic. (Source: McChesney EQ, Fitch CD. 4-Aminoquinolines. In: Peters W, Richards WHG, editors. Antimalarial drugs II. Current antimalarials and new drug developments. Berlin: Springer; 1984. p. 3–60.) LD50: 2.9547 mol/kg

Important announcement about anti-inflammatories

It turns out that taking anti-inflammatories can actually make things worse if you have COVID-19. The video and research are via this link.

Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial

Conclusion Overall advice to use steam inhalation, or ibuprofen rather than paracetamol, does not help control symptoms in patients with acute respiratory tract infections and must be balanced against the possible progression of symptoms during the next month for a minority of patients. Advice to use ibuprofen might help short term control of symptoms in those with chest infections and in children.

CORD-19 | Semantic Scholar

CORD-19 (COVID-19 Open Research Dataset) is a free resource of over 29,000 scholarly articles about COVID-19 and the coronavirus family of viruses.

Japanese flu drug 'clearly effective' in treating coronavirus, says China

Shares in Fujifilm Toyama Chemical, which developed favipiravir, surged after praise by Chinese official

medRxiv

Countless researchers are busy tearing apart the coronavirus. The resulting plethora of activity has resulted in the posting of over 300 papers on MedRXiv, a repository for medical-research work that has not yet been formally peer-reviewed and published, since February 1st, and the depositing of hundreds of genome sequences in public databases. The assault on the vaccine is not just taking place in the lab. As of February 28th China’s Clinical Trial Registry listed 105 trials of drugs and vaccines intended to combat SARS-CoV-2 either already recruiting patients or proposing to do so. As of March 11th its American equivalent, the National Library of Medicine, listed 84. This might seem premature, considering how recently the virus became known to science; is not drug development notoriously slow? But the reasonably well-understood basic biology of the virus makes it possible to work out which existing drugs have some chance of success, and that provides the basis for at least a little hope.

Vitamin D and immunity

A study of over 10,000 people indicates that vitamin D supplementation can reduce your risk of respiratory (eg: coronavirus) illness by up to 70%.

Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus

In light of worldwide concern regarding the recent outbreak of a deadly novel strain of coronavirus in China, it is fortuitous that two recent discoveries point the way to effective nutraceutical measures for potentiating the type 1 interferon response to RNA viruses.

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